Contraceptive efficacy of Plumbago zeylanica root extract (50% etoh) in male albino rats with special emphasis on testicular cell population dynamics
نویسندگان
چکیده
The administration of Plumbago zeylanica root (50% EtOH) extract to |intact rats at the dose of 150 mg/kg [body weight for 60 days caused arrest of spermatogenesis. The diameter of seminiferous tubules and Leydig cell nuclei were reduced. The production of spermatocytes (primary and secondary) and spermatids were significantly reduced (P£ 0.001; 83.57%, 89.69% and 69.47% respectively). The total number of immature and mature Leydig cells was significantly decreased (P£ 0.001; 68.62% and 71.14%), where as degenerating cells were significantly increased (58.26%). Decreased testicular cell population reflects contraceptive or antispermatogenic nature of Plumbago zeylanica extract and may be of vital use in fertility control.
منابع مشابه
Antifertility Activity of Stems of Plumbago zeylanica Linn. in Female Albino Rats
In the present study, Plumbago zeylanica Linn. (Plumbaginaceae) , one of the folk medicinal plants commonly used as antifertility agent was evaluated for its antifertility effect. Five successive solvent extracts, petroleum ether, chloroform, acetone, ethanol and water extracts, of the stems of P. zeylanica were studied on estrous cycle at two dose levels, 200 and 400 mg/kg respectively....
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